Cortisol: Testosterone ratio and homocysteine levels in patients with acute myocardial infarction

Stressful experiences include major life events, trauma, and abuse and are sometimes related to the environment in the home, workplace, or neighborhood. Acute stress and chronic can both have long-term consequences. Therefore, this study was carried out to investigate cortisol, total testosterone and total homocysteine (tHcy) status in acute myocardial infarction (AMI). Thirty AMI patients were included and diagnosed based on clinical examination, laboratory investigations, electrocardiogram, angiography and other tests. The blood samples were analyzed for cortisol, total testosterone and tHcy. Significantly increased levels of serum cortisol and tHcy, and decreased level of total testosterone were noticed in the patients group as compared to control subjects. Whereas, we found positive and significant correlation between cortisol : testosterone (C/T) ratio and tHcy, and mean blood pressure in AMI patients. This study suggests that, some methods require which reduces the C/T ratio and homocysteine levels may reduce the risk of AMI.